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The quaternary ammonium linker represents a significant advance in linker technology, enabling stable conjugation of payloads with tertiaryamine residues.
3
The tertiaryamine is then distilled off, the residual products separated by filtration and finally hydrolysed by a caustic alkali.
4
External to the aromatic site, there is another weaker and less gating-dependent site for the tertiaryamine chain in the latter two drugs.
5
The quaternary ammonium linker was then applied to a tubulysin antimitotic drug that contained an N-terminal tertiaryamine that was important for activity.
Usage of tertiary amines in inglês
1
The secondary and tertiaryamines do not give this reaction.
2
When heated with alkyl or aryl iodides, they are converted into secondary and tertiaryamines.
3
The mixed tertiaryamines are produced by the action of alkyl halides on the primary amines.
4
The tertiaryamines may also be of two types, the purely aromatic and the mixed type.
5
A new carbamoylation of tertiaryamines is reported.
6
The primary, secondary and tertiaryamines may be readily distinguished by their behaviour with various reagents.
7
The tertiaryamines possess the power of combining with one molecular proportion of an alkyl iodide to form quaternary ammonium salts.